That is the share of the 25,000 US cities that will lose a quarter of their populations or more by the end of the century. That according to a new analysis from economists at the University of Chicago. The study also says that if US fertility rates continue to decline and the exodus from cities gets worse, as many as two-third of cities could see their populations shrink significantly. While 2100 may seem a long way from now, the impact of the trend is already being felt in many cities. Eventually, the study found, “The implications of this massive decline in population will bring unprecedented challenges, possibly leading to disruptions in basic services like transit, clean water, electricity and internet access, as cities shrink and populations age.” This on-going trend was sped up during Covid, as working from home began common and enabled Americans to move out of cities and into more rural areas. The report added that the depopulation numbers will be higher in the Northeast and Midwest regions of the country than in the South and West – all this with major supply chain implications.